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KMID : 0620920160480010002
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Experimental & Molecular Medicine
2016 Volume.48 No. 1 p.2 ~ p.2
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The role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistance
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Yoon Mee-Sup
Choi Cheol-Soo
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Abstract
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Mammalian target of rapamycin (mTOR) controls cell growth and metabolism in response to nutrients, energy, and growth factors. Recent findings have placed the lysosome at the core of mTOR complex 1 (mTORC1) regulation by amino acids. Two parallel pathways, Rag GTPase-Ragulator and Vps34-phospholipase D1 (PLD1), regulate mTOR activation on the lysosome. This review describes the recent advances in understanding amino acid-induced mTOR signaling with a particular focus on the role of mTOR in insulin resistance.
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